Achievements

Articles (peer-reviewed)

  1.  Kida YS*, Kawamura T*, Zong W*, Sogo T, Jacinto S, Shigeno A, Kushige H, Yoshihara E, Liddle C, Ecker JR, Yu RT, Atkins AR, Downes M, Evans RM.  ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency.  (*Equal co-first author)
    Cell Stem Cell. 2015;16:547-555. doi: 10.1016/j.stem.2015.03.001.

  2.  Koga M, Matsuda M, Kawamura T, Sogo T, Shigeno A, Nishida E, Ebisuya M.
    Foxd1 is a mediator and indicator of the cell reprogramming process.
    Nature Commun. 2014;5:3197. doi: 10.1038/ncomms4197.

  3.  Sunagawa Y, Morimoto T, Wada H, Takaya T, Katanasaka Y, Kawamura T, Yanagi S, Marui A, Sakata R, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K.  A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats. 
    Circ J. 2011;75:2151-2159.

  4.  Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Watanabe S, Takaya T, Tamaki Y, Takanabe-Mori R, Wada H, Hasegawa K, Iwanaga Y, Kawamura T, Kita T, Kimura T. 
    MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes. 
    Mol Cell Biol. 2011;31:744-755.

  5.  Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba  S, Heike T, Nakahata T, Hasegawa K.  Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes. 
    J Cell Physiol. 2011;226:248-254.

  6.  Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T.  Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. 
    Cardiovasc Res. 2010;88:314-323.

  7.  Sugii S, Kida Y, Kawamura T, Suzuki J, Vassena R, Yin YQ, Lutz MK, Berggren WT, Izpisúa-Belmonte JC, Evans RM.  Human and mouse adipose-derived cells support feeder independent induction of pluripotent stem cells. 
    Proc Natl Acad Sci U S A. 2010;107:3558-3563.

  8.  Takaya T, Wada H, Morimoto T, Sunagawa Y, Kawamura T, Takanabe-Mori R, Shimatsu A, Fujita Y, Sato Y, Fujita M, Kimura T, Sawamura T, Hasegawa K.  Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts. 
    Circ J. 2010;74:723-729.

  9.  Sunagawa Y, Morimoto T, Takaya T, Kaichi S, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K.  Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. 
    J Biol Chem. 2010;285:9556-9568.

  10.  Yoshida Y, Morimoto T, Takaya T, Kawamura T, Sunagawa Y, Wada H, Fujita M, Shimatsu A, Kita T, Hasegawa K.  Aldosterone Signaling Associates with p300/GATA4 Transcriptional Pathway During Hypertrophic Responses of Cardiomyocytes. 
    Circ J. 2010;74:156-162.

  11.  Wada H, Satoh N, Kitaoka S, Ono K, Shinjo D, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu, Hasegawa K.  Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance. 
    Atherosclerosis. 2010;208:512-517.

  12. Kawamura T*, Suzuki J*, Wang YV, Menendez S, Batlle Morera L, Raya A, Wahl GM, Izpisúa-Belmonte JC.  Linking the p53 tumour suppressor pathway to somatic cell reprogramming.  (*Equal co-first author)
    Nature. 2009;460:1140-1144.

  13.  Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, Wada H, Kita T, Shimatsu A, Hasegawa K.  MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells. 
    Circ J. 2009;73:1492-1497.

  14. Wada H, Abe M, Ono K, Morimoto T, Kawamura T, Takaya T, Satoh N, Fujita M, Kita T, Shimatsu A, Hasegawa K.  Statins activate GATA-6 and induce differentiated vascular smooth muscle cells. 
    Biochem Biophys Res Commun. 2008;374:731-736.

  15. Morimoto T, Fujita M, Kawamura T, Sunagawa Y, Takaya T, Wada H, Shimatsu A, Kita T, Hasegawa K.  Myocardial regulation of p300 and p53 by doxorubicin involves ubiquitin pathways. 
    Circ J. 2008;72:1506-1511.

  16. Horie T, Ono K, Kinoshita M, Nishi H, Nagao K, Kawamura T, Abe Y, Wada H, Shimatsu A, Kita T, Hasegawa K.  TG-interacting factor is required for the differentiation of preadipocytes. 
    J Lipid Res. 2008;49:1224-1234.

  17. Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H, Nagasawa A, Komeda M, Fujita M, Shimatsu A, Kita T, Hasegawa K.  The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. 
    J Clin Invest. 2008;118:868-878.

  18. Takaya T, Kawamura T, Morimoto T, Ono K, Kita T, Shimatsu A, Hasegawa K.   Identification of p300-targeted acetylated residues in GATA-4 during hypertrophic responses in cardiac myocytes. 
    J Biol Chem. 2008;283:9828-9835.

  19. Horie T, Ono K, Nagao K, Nishi H, Kinoshita M, Kawamura T, Wada H, Shimatsu A, Kita T, Hasegawa K.  Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes. 
    J Cell Physiol. 2008;215:733-742.

  20. Hosseinkhani M, Hasegawa K, Ono K, Kawamura T, Takaya T, Morimoto T, Wada H, Shimatsu A, Prat SG, Suemori H, Nakatsuji N, Kita T.  Trichostatin A induces myocardial differentiation of monkey ES cells. 
    Biochem Biophys Res Commun. 2007;356:386-391.

  21. Abe Y, Ono K, Kawamura T, Wada H, Kita T, Shimatsu A, Hasegawa K.  Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation. 
    Am J Physiol Heart Circ Physiol. 2007;292:H2387-2396.

  22. Kanemitsu N, Tambara K, Premaratne GU, Kimura Y, Tomita S, Kawamura T, Hasegawa K, Tabata Y, Komeda M.  Insulin-like growth factor-1 enhances the efficacy of myoblast transplantation with its multiple functions in the chronic myocardial infarction rat model. 
    J Heart Lung Transplant. 2006;25:1253-1262.

  23. Miyamoto S*, Kawamura T*, Morimoto T, Ono K, Wada H, Kawase Y, Matsumori A, Nishio R, Kita T, Hasegawa K. (*Equal co-first author)  Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo
    Circulation. 2006;113:679-690.

  24. Kawamura T, Ono K, Morimoto T, Wada H, Hirai M, Hidaka K, Morisaki T, Heike T, Nakahata T, Kita T, Hasegawa K.  Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. 
    J Biol Chem. 2005;280:19682-19688.

  25. Ehara N, Ono K, Morimoto T, Kawamura T, Abe M, Hasegawa K.  The possible role of peroxisome proliferator-activated receptor gamma in heart failure. 
    Exp Clin Cardiol. 2004;9:169-173.

  26. Kawamura T, Hasegawa K, Morimoto T, Iwakura A, Nishina T, Nomoto T, Komeda M.  Down-regulation of endothelin-1 and alteration of apoptosis signaling following left ventricular volume reduction surgery in heart failure of adult rats. 
    J Cardiovasc Pharmacol. 2004;44, Supple 1:S366-S371.

  27. Ehara N, Hasegawa K, Ono K, Kawamura T, Iwai-Kanai E, Morimoto T, Akao M, Adachi S, Kita T.  Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. 
    Biochem Biophys Res Commun. 2004;321:345-349.

  28. Hirai M, Ono K, Morimoto T, Kawamura T, Wada H, Kita T, Hasegawa K.  FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes. 
    J Biol Chem. 2004;279:37640-37650.

  29. Kawamura T, Ono K, Morimoto T, Akao M, Iwai-Kanai E, Wada H, Sowa N, Kita T, Hasegawa K.  Endothelin-1-dependent nuclear factor activated T lymphcyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes. 
    Circ Res. 2004;94:1492-1499.

  30. Ono K, Iwanaga Y, Hirayama M, Kawamura T, Sowa N, Hasegawa K.  Contribution of caveolin-1alpha and Akt to TNF-alpha-induced cell death. 
    Am J Physiol Lung Cell Mol Physiol. 2004;287:L201-209.

  31. Kawamura T, Hasegawa K, Morimoto T, Iwai-Kanai E, Miyamoto S, Kawase Y, Ono K, Wada H, Akao M, Kita T.  Expression of p300 protects cardiac myocytes from apoptosis in vivo. 
    Biochem Biophys Res Commun. 2004;315:733-738.

  32. Yanazume T, Morimoto T, Wada H, Kawamura T, Hasegawa K.  Biological role of p300 in cardiac myocytes. 
    Mol Cell Biochem. 2003;248:115-119.

  33. Iwai-Kanai E, Hasegawa K, Adachi S, Fujita M, Akao M, Kawamura T, Kita T.  Effects of endothelin-1 on mitochondrial function during the protection against myocardial cell apoptosis. 
    Biochem Biophys Res Commun. 2003;305:898-903.

  34. Yanazume T*, Hasegawa K, Morimoto T*, Kawamura T*, Wada H, Matsumori A, Kawase Y, Hirai M, Kita T. (*Equal co-first author)  Cardiac p300 is involved in myocyte growth with decompensated heart failure. 
    Mol Cell Biol. 2003;23:3593-3606.

  35. Abe M, Hasegawa K, Wada H, Morimoto T, Yanazume T, Kawamura T, Hirai M, Furukawa Y, Kita T.  GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. 
    Arterioscler Thromb Vasc Biol. 2003;23:404-410.

  36. Kataoka K, Hasegawa K, Sawamura T, Fujita M, Yanazume T, Iwai-Kanai E, Kawamura T, Hirai T, Kita T, Nohara R.  LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury. 
    Biochem Biophys Res Commun. 2003;300:656-660.

  37. Yanazume T, Hasegawa K, Wada H, Morimoto T, Abe M, Kawamura T, Sasayama S.  Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. 
    J Biol Chem. 2002;277:8618-8625.

  38. Kakita T, Hasegawa K, Iwai-Kanai E, Adachi S, Morimoto T, Wada H, Kawamura T, Yanazume T, Sasayama S.  Calcineurin pathway is required for endothelin-1-mediated protection against oxidant stress-induced apoptosis in cardiac myocytes. 
    Circ Res. 2001;88:1239-1246.