研究成果
2021年度
Harada Y, Tanaka T, Arai Y, Isomoto Y, Nakano A, Nakao S, Urasaki A, Watanabe Y, Kawamura T, Nakagawa O. ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development.
Genes Cells 2021;26(8):611-626. doi: 10.1111/gtc.12874.
Akagi Y, Mori N, Kawamura T, Takayama Y, Kida YS. Non-invasive cell classification using the Paint Raman Express Spectroscopy System (PRESS).
Sci Rep. 2021;11(1):8818. doi: 10.1038/s41598-021-88056-3.
Kinugasa-Katayama Y, Watanabe Y, Hisamitsu T, Arima Y, Liu NM, Tomimatsu A, Harada Y, Arai Y, Urasaki A, Kawamura T, Saito Y, Nakagawa O. Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation.
Genesis. 2021;59(4):e23416. doi: 10.1002/dvg.23416.
2020年度
Seya D, Ihara D, Shirai M, Kawamura T, Watanabe Y, Nakagawa O. A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis.
Dev Growth Differ. 2021;63(1):82-92. doi: 10.1111/dgd.12707.
Watanabe Y, Seya D, Ihara D, Ishii1 S, Uemoto T, Kubo A, Arai Y, Isomoto Y, Nakano A, Abe T, Shigeta M, Kawamura T, Saito Y, Ogura T, Nakagawa O. Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription.
J Biol Chem. 2020;295(51):17632-17645. doi: 10.1074/jbc.RA120.015003.
Nakao S, Miyazaki S, Mizuguchi M, Yanagisawa K, Kawamura T. Molecular basis of cardiac impulse generation in sinoatrial node in health and disease.
Advances in Animal Cardiology. 2020;53(2):1-11.
Iwagishi R, Tanaka R, Seto M, Takagi T, Norioka N, Ueyama T, Kawamura T, Takagi J, Ogawa Y, Shirakabe K. Negatively charged amino acids in the stalk region of membrane proteins reduce ectodomain shedding.
J Biol Chem. 2020;295(35):12343-12352. doi: 10.1074/jbc.RA120.013758.
Ishida T, Nakao S, Ueyama T, Harada Y, Kawamura T. Metabolic remodeling during somatic cell reprogramming to induced pluripotent stem cells: involvement of hypoxia-inducible factor 1.
Inflamm Regen. 2020;40:8. doi: 10.1186/s41232-020-00117-8. eCollection 2020.
Ihara D, Watanabe Y, Seya D, Arai Y, Isomoto Y, Nakano A, Kubo A, Ogura T, Kawamura T, Nakagawa O. Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors.
Dev Biol. 2020;461(2):124-131. doi: 10.1016/j.ydbio.2020.02.001.
2019年度以前（抜粋）
Nakao S, Ihara D, Hasegawa K, Kawamura T. Applications of induced pluripotent stem cells in disease modelling and drug development for heart diseases.
Eur Cardiol. 2020;15:1-10. doi: 10.15420/ecr.2019.03.
Nakao S, Tsukamoto T, Ueyama T, Kawamura T. STAT3 for cardiac regenerative medicine: involvement in stem cell biology, pathophysiology, and bioengineering.
Int J Mol Sci. 2020;21(6):1937. doi: 10.3390/ijms21061937.
Tsukamoto T*, Sogo T*, Ueyama T*, Nakao S, Harada Y, Ihara D, Akagi Y, Kida YS, Hasegawa K, Nagamune T, Kawahara M, Kawamura T. Chimeric G-CSF receptor-mediated STAT3 activation contributes to efficient induction of cardiomyocytes from mouse induced pluripotent stem cells. (*Equal co-first author)
Biotechnol J. 2020;15(2) e1900052. doi: 10.1002/biot.201900052.
Araki M, Hisamitsu T, Kinugasa-Katayama Y, Tanaka T, Harada Y, Nakao S, Hanada S, Ishii S, Fujita M, Kawamura T, Saito Y, Nishiyama K, Watanabe Y, Nakagawa O. Serum/glucocorticoid regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells.
Angiogeneis. 2018;21(2):415-423. doi: 10.1007/s10456-018-9605-x.
Kida YS*, Kawamura T*, Zong W*, Sogo T, Jacinto S, Shigeno A, Kushige H, Yoshihara E, Liddle C, Ecker JR, Yu RT, Atkins AR, Downes M, Evans RM. ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. (*Equal co-first author)
Cell Stem Cell. 2015;16(5):547-555. doi: 10.1016/j.stem.2015.03.001.
Koga M, Matsuda M, Kawamura T, Sogo T, Shigeno A, Nishida E, Ebisuya M. Foxd1 is a mediator and indicator of the cell reprogramming process.
Nature Commun. 2014;5:3197.
Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Watanabe S, Takaya T, Tamaki Y, Takanabe-Mori R, Wada H, Hasegawa K, Iwanaga Y, Kawamura T, Kita T, Kimura T. MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes.
Mol Cell Biol. 2011;31:744-755.
Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K. Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes.
J Cell Physiol. 2011;226:248-254.
Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T. Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.
Cardiovasc Res. 2010;88:314-323.
Sugii S, Kida Y, Kawamura T, Suzuki J, Vassena R, Yin YQ, Lutz MK, Berggren WT, Izpisúa-Belmonte JC, Evans RM. Human and mouse adipose-derived cells support feeder independent induction of pluripotent stem cells.
Proc Natl Acad Sci U S A. 2010;107:3558-3563.
Takaya T, Wada H, Morimoto T, Sunagawa Y, Kawamura T, Takanabe-Mori R, Shimatsu A, Fujita Y, Sato Y, Fujita M, Kimura T, Sawamura T, Hasegawa K. Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts.
Circ J. 2010;74:723-729.
Sunagawa Y, Morimoto T, Takaya T, Kaichi S, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K. Cyclin-dpendent kinsase-9 is a novel component of p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiac myocytes.
J Biol Chem. 2010;285:9556-9568.
Yoshida Y, Morimoto T, Takaya T, Kawamura T, Sunagawa Y, Wada H, Fujita M, Shimatsu A, Kita T, Hasegawa K. Aldosterone Signaling Associates with p300/GATA4 Transcriptional Pathway During Hypertrophic Responses of Cardiomyocytes.
Circ J. 2010;74:156-162.
Wada H, Satoh N, Kitaoka S, Ono K, Shinjo D, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu, Hasegawa K. Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance.
Atherosclerosis. 2010;208:512-517.
Kawamura T*, Suzuki J*, Wang YV, Menendez S, Batlle Morera L, Raya A, Wahl GM, Izpisúa-Belmonte JC. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. (*Equal co-first author)
Nature. 2009;460:1140-1144.
Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, Wada H, Kita T, Shimatsu A, Hasegawa K. MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells.
Circ J. 2009;73:1492-1497.
Wada H, Abe M, Ono K, Morimoto T, Kawamura T, Takaya T, Satoh N, Fujita M, Kita T, Shimatsu A, Hasegawa K. Statins activate GATA-6 and induce differentiated vascular smooth muscle cells.
Biochem Biophys Res Commun. 2008;374:731-736.
Morimoto T, Fujita M, Kawamura T, Sunagawa Y, Takaya T, Wada H, Shimatsu A, Kita T, Hasegawa K. Myocardial regulation of p300 and p53 by doxorubicin involves ubiquitin pathways.
Circ J. 2008;72:1506-1511.
Horie T, Ono K, Kinoshita M, Nishi H, Nagao K, Kawamura T, Abe Y, Wada H, Shimatsu A, Kita T, Hasegawa K. TG-interacting factor is required for the differentiation of preadipocytes.
J Lipid Res. 2008;49:1224-1234.
Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H, Nagasawa A, Komeda M, Fujita M, Shimatsu A, Kita T, Hasegawa K. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats.
J Clin Invest. 2008;118:868-878.
Takaya T, Kawamura T, Morimoto T, Ono K, Kita T, Shimatsu A, Hasegawa K. Identification of p300-targeted acetylated residues in GATA-4 during hypertrophic responses in cardiac myocytes.
J Biol Chem. 2008;283:9828-9835.
Horie T, Ono K, Nagao K, Nishi H, Kinoshita M, Kawamura T, Wada H, Shimatsu A, Kita T, Hasegawa K. Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes.
J Cell Physiol. 2008;215:733-742.
Abe Y, Ono K, Kawamura T, Wada H, Kita T, Shimatsu A, Hasegawa K. Leptin induces elongation of cardiac myocyte and causes eccentric left ventricular dilatation with compensation.
Am J Physiol Heart Circ Physiol. 2007;292:H2387-2396.
Kanemitsu N, Tambara K, Premaratne GU, Kimura Y, Tomita S, Kawamura T, Hasegawa K, Tabata Y, Komeda M. Insulin-like growth factor-1 enhances the efficacy of myoblast transplantation with its multiple functions in the chronic myocardial infarction rat model.
J Heart Lung Transplant. 2006;25:1253-1262.
Miyamoto S*, Kawamura T*, Morimoto T, Ono K, Wada H, Kawase Y, Matsumori A, Nishio R, Kita T, Hasegawa K. Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling following myocardial infarction in adult mice in vivo. (*Equal co-first author)
Circulation. 2006;113:679-690.
Kawamura T, Ono K, Morimoto T, Wada H, Hirai M, Hidaka K, Morisaki T, Heike T, Nakahata T, Kita T, Hasegawa K. Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes.
J Biol Chem. 2005;280:19682-19688.
Kawamura T, Hasegawa K, Morimoto T, Iwakura A, Nishina T, Nomoto T, Komeda M. Down-regulation of endothelin-1 and alteration of apoptosis signaling following left ventricular volume reduction surgery in heart failure of adult rats.
J Cardiovasc Pharmacol. 2004;44, Supple 1:S366-S371.
Hirai M, Ono K, Morimoto T, Kawamura T, Wada H, Kita T, Hasegawa K. FOG-2 competes with GATA-4 for a transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes.
J Biol Chem. 2004;279:37640-37650.
Kawamura T, Ono K, Morimoto T, Akao M, Iwai-Kanai E, Wada H, Sowa N, Kita T, Hasegawa K. Endothelin-1-dependent nuclear factor activating T lymphcytes signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes.
Circ Res. 2004;94:1492-1499.
Ono K, Iwanaga Y, Hirayama M, Kawamura T, Sowa N, Hasegawa K. Contribution of caveolin-1alpha and Akt to TNF-alpha-induced cell death.
Am J Physiol Lung Cell Mol Physiol. 2004;287:L201-209.
Kawamura T, Hasegawa K, Morimoto T, Iwai-Kanai E, Miyamoto S, Kawase Y, Ono K, Wada H, Akao M, Kita T. Expression of p300 protects cardiac myocytes from apoptosis in vivo.
Biochem Biophys Res Commun. 2004;315:733-738.
Yanazume T*, Hasegawa K, Morimoto T*, Kawamura T*, Wada H, Matsumori A, Kawase Y, Hirai M, Kita T. Cardiac p300 is involved in myocyte growth with decompensated heart failure. (*Equal co-first author)
Mol Cell Biol. 2003;23:3593-3606.
Abe M, Hasegawa K, Wada H, Morimoto T, Yanazume T, Kawamura T, Hirai M, Furukawa Y, Kita T. GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells.
Arterioscler Thromb Vasc Biol. 2003;23:404-410.
Kataoka K, Hasegawa K, Sawamura T, Fujita M, Yanazume T, Iwai-Kanai E, Kawamura T, Hirai T, Kita T, Nohara R. LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury.
Biochem Biophys Res Commun. 2003;300:656-660.
Yanazume T, Hasegawa K, Wada H, Morimoto T, Abe M, Kawamura T, Sasayama S. Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy.
J Biol Chem. 2002;277:8618-8625.
Kakita T, Hasegawa K, Iwai-Kanai E, Adachi S, Morimoto T, Wada H, Kawamura T, Yanazume T, Sasayama S. Calcineurin pathway is required for endothelin-1-mediated protection against oxidant stress-induced apoptosis in cardiac myocytes.
Circ Res. 2001;88:1239-1246.